Highlighted for enoxaparin
- Enoxaparin solution for injection is available as a generic and brand name drug.Trade name: Lovenox.
- Enoxaparin is injected subcutaneously (under the skin). Your doctor will show you how to give yourself this medicine.
- Enoxaparin is used to prevent blood clots in people in the hospital or at home. It is also used to treat existing blood clots at home or in the hospital.
FDA Warning: Spinal Hemorrhage
- This medication has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to the potentially dangerous effects of drugs.
- If you receive anesthesia through the spine or have a procedure that involves a spinal tap, this medicine may increase the risk of bleeding in that area. This can lead to permanent or long-term paralysis (inability to move your legs). Your doctor should watch you closely for signs of this type of bleeding.
Was it helpful?
- bleeding:This medicine increases the risk of bleeding. This can cause nosebleeds, increased bruising, increased bleeding from cuts, bleeding gums after brushing or flossing, blood in the urine, or red or black stools. Tell your doctor if you experience any of these symptoms.
- low platelets:In rare cases, this medicine can reduce platelets. Platelets are necessary for blood clotting. This further increases the risk of bleeding. Your doctor will check your platelet levels.
Enoxaparin solution for injection is a prescription drug available as a brand name drug.Lovenox. It is also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in all strengths or forms, such as the branded version.
It is available as a solution for injection in a pre-filled syringe. It is also available as a solution for injection in a vial, to be administered by a healthcare professional only. Enoxaparin is a self-injectable drug.
Because it is used?
Enoxaparin is used to thin the blood. Prevents blood from forming clots. Blood clots are dangerous because they can cause severe blockages in blood vessels. This can cause a stroke or heart attack.
This medication is used to prevent blood clots in hospitalized people. It can be used if you are too sick to move or are having a heart attack.
It is also used to prevent blood clots at home after stomach surgery or hip or knee replacement. This medication is also used to treat existing blood clots in the hospital or at home. A blood clot can be treated at home as long as it is not in the lungs.
This medication works quickly, so it may be the first blood thinner your doctor prescribes. You may need to take this medication until you can take oral anticoagulants. Oral anticoagulants take longer to work.
Enoxaparin can be used as part of combination therapy. This means that you may need to take it with other medicines. Carefully follow your doctor's instructions, as you may need to start or stop taking this medication or another blood thinner at specific times.
How it works
Enoxaparin belongs to a group of medicines called anticoagulants. A drug class is a group of drugs that work in a similar way. These drugs are often used to treat similar conditions.
Enoxaparin works by blocking a protein in your body that causes clotting. This prevents the formation of blood clots. If you have a blood clot, it will keep it from getting worse while your body breaks down the clot.
(Video) Enoxaparin - Mechanism, precautions, side effects & uses
Enoxaparin solution for injection may cause pain or bruising of the skin at the injection site. This may be more likely when you first start taking the medicine or when your doctor increases your dose. This medicine can also cause other side effects.
The most common side effects
The more common side effects of enoxaparin can include:
- bleeding
- anemia (lack of healthy red blood cells)
- pain and bruising at the injection site
- fever
- leg swelling
If these effects are mild, they may go away in a few days to a few weeks. If they are more severe or do not go away, contact your doctor or pharmacist.
serious side effects
Call your doctor right away if you experience serious side effects. Call 911 if your symptoms seem life-threatening or if you think you have a medical emergency. Serious side effects and their symptoms may include the following:
- A rebound shot. This is a stroke that can happen when you stop taking this medicine. Symptoms may include:
- problems with speaking or understanding
- loss of control or numbness in the face, arms, or legs
- vision problems in one or both eyes
- headache
- trouble walking
- bleeding. Symptoms may include:
- dor abdominal
- black or tarry stools
- nosebleeds
- bleeding gums
- coughing up blood
- bruises more easily than usual
- vomiting blood
- Rebound blood clots. These blood clots can form when you stop taking this medicine. Symptoms may include:
- chest pain
- Respiratory problems
- warmth, redness, or swelling in the hands or feet
Exemption:Our goal is to provide you with the most relevant and up-to-date information. However, because medications work differently for everyone, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.
Enoxaparin solution for injection may interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This could be harmful or stop the medicine from working as well.
To avoid interactions, your doctor must carefully manage all your medications. Be sure to tell your doctor about any medications, vitamins, or herbs you are taking. To find out how this medicine might interact with something else you are taking, talk to your doctor or pharmacist.
Taking enoxaparin with certain medications increases the risk of side effects. This is because enoxaparin and these other drugs can cause the same side effects. As a result, these side effects may increase. Examples of these drugs include:
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, or naproxen.These medicines can lower your platelets. If you take them with enoxaparin, the risk of bleeding is increased.
- Platelet inhibitors such as clopidogrel, prasugrel, ticagrelor, or dipyridamole.These medicines can lower your platelets. If you take them with enoxaparin, the risk of bleeding is increased.
- Herbal supplements such as ginkgo biloba, fish oil, garlic, ginseng, and ginger.These supplements can reduce platelets. If you take them with enoxaparin, the risk of bleeding is increased.
Exemption:Our goal is to provide you with the most relevant and up-to-date information. However, because drugs interact differently in different people, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always talk to your doctor about possible interactions with any prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs you take.
Enoxaparin injection comes with several warnings.
allergy notification
Enoxaparin can cause a severe allergic reaction. Symptoms may include:
- Respiratory problems
- swelling of the throat or tongue
- urticaria
- skin irritation
If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.
Do not take this medicine again if you have already had an allergic reaction.Taking it again can be fatal (cause death).
Do not take this medicine if you have had an allergic reaction to heparin, pork products, or benzyl alcohol.
Notifications for people with certain health problems
For people with kidney problems:If you have kidney problems or a history of kidney disease, you may not be able to clear this medication from your body as well. This can cause the medicine to build up in your body and cause more side effects. Your doctor may reduce the dose if you have severe kidney disease.
For people with low body weight:Women who weigh less than 45 kg (99 lbs) and men who weigh less than 57 kg (126 lbs) may have higher levels of enoxaparin in their bodies. Your doctor may monitor you more closely for signs of bleeding. They may also give you a lower dose to avoid side effects.
For people with high body weight:This medication has not been well studied in people who are obese (body mass index or BMI of 30 or more). If you are obese, your doctor may monitor you more closely for signs of a clot. They may also do tests to see if the dose needs to be changed.
For people with diabetes-related eye problems:This medicine can cause bleeding. If you have diabetic retinopathy, it means that the blood vessels in your eyes are already leaking blood. Taking this medicine puts you at high risk for bleeding (serious and life-threatening bleeding).
For people with high blood pressure:This medicine can cause bleeding. If you have uncontrolled high blood pressure, you are at high risk of bleeding (serious and life-threatening bleeding).
For people with a history of stomach ulcers:If you have recently had a stomach ulcer, ask your doctor if this medicine is safe for you.
For people with platelet disorders:You should not use this medicine if you have heparin-induced thrombocytopenia (a platelet problem associated with the use of heparin or similar medicines). If you have low platelets, ask your doctor if this medication is safe for you.
For people with certain heart valves:If you have a mechanical prosthetic heart valve, ask your doctor if this medication is safe for you. This drug has not been well studied in people with this type of heart valve.
For people with bleeding disorders:If you have a bleeding disorder, ask your doctor if this medication is safe for you. You are already at high risk of bleeding and this drug will further increase your risk.
Notifications for other groups
For pregnant women:Enoxaparin is a category B pregnancy drug. This means two things:
- Animal studies have shown that there is no risk to the fetus when the mother takes the drug.
- There are not enough human studies to show if the drug poses a risk to the fetus.
Talk to your doctor if you are pregnant or plan to become pregnant. Animal studies do not always predict how humans would react. Therefore, this medicine should only be used during pregnancy if necessary. Contact your doctor immediately if you become pregnant while taking this medicine.
For women who are breastfeeding:Enoxaparin can pass into breast milk and cause side effects in breastfed infants. Talk to your doctor if you are breastfeeding your baby. You may need to decide whether to stop breastfeeding or stop taking this medicine.
For the elderly:Older people's kidneys may not work as well as they used to. This can slow down your body to process the medicine. As a result, more of the drug stays in your body longer. This increases the risk of side effects. If you are over 65 years of age, you may be at increased risk of bleeding while taking this medicine.
For children:This medicine has not been tested in children. It should not be used by persons under the age of 18.
This dosing information is for enoxaparin injection solution. Not all possible dosages and forms of medication may be included here. Your dosage, form of medication, and how often you take the medication will depend on:
- your age
- condition to treat
- How serious is your condition?
- other medical conditions you have
- how do you react to the first dose
forms and powers
Generic:enoxaparin
- Form:Pre-filled syringes for injection
- Cash:30 mg, 40 mg, 60 mg, 80 mg, 100 mg, 120 mg y 150 mg
When:Lovenox
- Form:Pre-filled syringes for injection
- Cash:30 mg, 40 mg, 60 mg, 80 mg, 100 mg, 120 mg y 150 mg
Dosage for prevention of deep vein thrombosis
Adult dose (18 to 64 years)
- People who have had abdominal surgery:40 mg injected once a day
- People who have had knee replacement surgery:30 mg injected every 12 hours
- People who have had hip replacement surgery:30 mg injected every 12 hours or 40 mg injected once daily
- People who are in the hospital and cannot move much:40 mg injected once a day
Dose for children (0 to 17 years)
This medicine has not been confirmed to be safe and effective for use in people under 18 years of age.
Dosage for the elderly (65 years and older)
Older people's kidneys may not work as well as they used to. This can slow down your body to process the medicine. As a result, more of the drug stays in your body longer. This increases the risk of side effects. Your doctor may start you on a reduced dose or a different dosing schedule. This can help prevent levels of this medicine from building up too much in your body.
Special Considerations
People with severe kidney problems:
- People who have had abdominal surgery:30 mg injected once a day
- People who have had hip or knee replacement surgery:30 mg injected once a day
- People who are in the hospital and cannot move much:30 mg injected once a day
Dosage for treatment of deep vein thrombosis with or without pulmonary clots
Adult dose (18 to 64 years)
- Home treatment for people without clots in the lungs:1 mg per kg of body weight is injected every 12 hours
- Hospital treatment for people with or without clots in the lungs:1 mg per kg of body weight injected every 12 hours or 1.5 mg per kg of body weight injected once daily. This will be done by a healthcare worker at the hospital.
Dose for children (0 to 17 years)
This medicine has not been confirmed to be safe and effective for use in people under 18 years of age.
Dosage for the elderly (65 years and older)
Older people's kidneys may not work as well as they used to. This can slow down your body to process the medicine. As a result, more of the drug stays in your body longer. This increases the risk of side effects. Your doctor may start you on a reduced dose or a different dosing schedule. This can help prevent levels of this medicine from building up too much in your body.
Special Considerations
People with severe kidney problems:
- Home treatment for people without clots in the lungs:1 mg per kg of body weight is injected once a day
- Hospital treatment for people with or without clots in the lungs:1 mg per kg of body weight is injected once a day. This will be done by a healthcare worker at the hospital.
Dosage for prevention of heart problems during a heart attack
Adult dose (18 to 64 years)
1 mg per kg of body weight is injected every 12 hours while you are in the hospital
Dose for children (0 to 17 years)
This medicine has not been confirmed to be safe and effective for use in people under 18 years of age.
Dosage for the elderly (65 years and older)
Older people's kidneys may not work as well as they used to. This can slow down your body to process the medicine. As a result, more of the drug stays in your body longer. This increases the risk of side effects. Your doctor may start you on a reduced dose or a different dosing schedule. This can help prevent levels of this medicine from building up too much in your body.
Special Considerations
severe kidney problems: 1 mg per kg of body weight injected once daily. This will be done by a healthcare worker at the hospital.
Dosage for treatment of heart attack
Adult dose (18 to 64 years)
A typical dose is a 30 mg intravenous (into a vein) injection given in a hospital, plus a 1 mg/kg subcutaneous injection. Then 1 mg per kg of body weight will be injected every 12 hours. This will be done by a healthcare worker at the hospital.
Dose for children (0 to 17 years)
This medicine has not been confirmed to be safe and effective for use in people under 18 years of age.
Dosage for the elderly (65 to 74)
A typical dose is an intravenous (into a vein) 30 mg injection plus a 1 mg/kg injection under the skin. Then, in the hospital, 1 mg per kg of body weight will be injected every 12 hours.
Dosage for the elderly (75 years and older)
0.75 mg per kg of body weight injected every 12 hours. This will be done by a healthcare worker at the hospital.
Special Considerations
- Serious kidney problems (18 to 74 years):A typical dose is an intravenous (into a vein) 30 mg injection plus a 1 mg/kg injection under the skin. Then, in the hospital, 1 mg per kg of body weight will be injected once a day.
- Severe kidney problems (over 75 years):The typical dose is 1 mg per kg of body weight injected once a day. This will be done by a healthcare worker at the hospital.
Exemption:Our goal is to provide you with the most relevant and up-to-date information. However, because medications work differently for everyone, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always talk to your doctor or pharmacist about the dosages that are right for you.
(Video) 💊ENOXAPARIN (LOVENOX): Side effects, mechanism of action, dosing, injection of Enoxaparin (Lovenox)
Enoxaparin solution for injection is used for short-term treatment. It comes with risks if not taken as prescribed.
If you stop taking the medicine suddenly or not at all:You will have a higher risk of a blood clot. This can lead to serious problems such as stroke or death. Take this medicine at the time prescribed by your doctor. Do not stop taking it without first talking to your doctor.
If you forget a dose or do not take the medicine on time:Your medicine may not work as well or may stop working altogether. For this medicine to work well, a certain amount must be in your body at all times.
If you take too much:You may have dangerous levels of the drug in your body. This can cause bleeding. Symptoms of an overdose of this medication may include:
- dor abdominal
- black or tarry stools
- nosebleeds
- bleeding gums
- coughing up blood
- bruises more easily than usual
- vomiting blood
If you think you have taken too much of this medicine, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose:Take your dose as soon as you remember. But if you remember only a few hours before your next scheduled dose, take only one dose. Never try to hit it by firing two shots at once. This can lead to dangerous side effects.
How to tell if the medicine is working:You will not be able to feel if this medicine is working. Your doctor will do blood tests to see if this medicine is working for you.
Keep this in mind if your doctor prescribes enoxaparin solution for injection.
In general
Not all pharmacies stock this medication. Be sure to call ahead when you get your prescription.
Store
Store enoxaparin at room temperature. Keep at 25°C (77°F). Keep it away from light. Do not store this medication in wet or damp areas, such as bathrooms.
filling in
The prescription for this medication is refillable. You should not need a new prescription to refill this medication. Your doctor will write the number of authorized refills on your prescription.
A trip
When traveling with your medication:
- Always carry your medicine with you. When you fly, never put it in your checked baggage. Keep it in your hand luggage.
- Don't worry about the X-ray machines at the airport. They can't harm your medicines.
- You may need to show the pharmacy label on your medication to the airport staff. Always carry the original labeled box of the prescription medication with you.
- Do not put this medication in the glove compartment or leave it in the car. Avoid doing this when the weather is too hot or too cold.
independent management
Your doctor will show you how to inject this medicine.
clinical monitoring
You and your doctor need to monitor certain health problems. This can help keep you safe while you are taking this medicine. These questions include:
- Kidney function.Your doctor may do blood tests to check how well your kidneys are working. If your kidneys are not working well, your doctor may reduce the dose of this medicine.
- Platelet count.Your doctor will check your platelet levels. This is done to ensure that you are not at high risk of bleeding or do not experience any side effects.
- Anti-Xa levels.These levels can help your doctor know how well this medicine is working for you. This is especially important if you are obese or have kidney problems.
Hidden costs
You may need to purchase the following to inject this medication:
- alcohol wipes
- sharps container (trash can used to safely dispose of used lancets)
Yeah
Many insurance companies require prior approval for this drug. This means that your doctor will need to get approval from your insurance company before paying for the prescription.
There are other medications available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about other medication options that may be right for you.
Exemption:Healthline has made every effort to ensure that all information is factually accurate, complete, and up-to-date. However, this article should not be used as a substitute for the knowledge and experience of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information in this document is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or side effects. The absence of warnings or other information for a particular drug does not mean that the drug or drug combination is safe, effective, or appropriate for all patients or for all specific uses.