Konazole (Ketoconazole) Use, Dosage, Side Effects, FAQ - MedicinesFAQ (2023)

Konazol (ketokonazol)

Conazole (ketoconazole) interferes with triglyceride and phospholipid biosynthesis by blocking fungal CYP450, thereby altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes, leading to the buildup of toxic concentrations of hydrogen peroxide.

Conazole (ketoconazole), like other azole antifungals, is a fungistatic that causes the growth of fungal cells to stop, thus preventing the growth and spread of fungi throughout the body.

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Treatment of superficial and deep mycoses:

  • Dermatophytic and/or fungal infections of the skin, hair and nails (dermatomycosis, onychomycosis, perionyx, tinea versicolor, chronic mucocutaneous candidiasis, etc.), especially when local treatment is difficult or ineffective due to the involvement of large areas of skin or lesions affecting the deeper dermal layers, nails and hair
  • Fungal infections of the mouth (thrush, perleche) and gastrointestinal tract
  • Vaginal candidiasis, especially chronic recurrent cases or cases that respond poorly to local treatment
  • Systemic fungal infections such as systemic candidiasis, paracoccidioidomycosis, histoplasmosis, coccidioidomycosis, etc.

Maintenance treatment to prevent relapses in systemic fungal infections and chronic mucocutaneous candidiasis. Prophylactic treatment to prevent fungal infections in patients with reduced host defences, eg cancer patients, organ transplants and burns.

Conazole (Ketoconazole) is also used for the associated treatment of these conditions: bacterial vaginosis (BV), blastomycosis, systemic candidiasis, chromomycosis, chronic mucocutaneous candidiasis (CMC), coccidioidomycosis, dandruff, endogenous Cushing's syndrome, histoplasmosis, infections, fungi, Paracoccidioidomycosis, Seborrheic dermatitis, Tinea corporis caused by Epidermophyton floccosumin, Tinea corporis caused by Trichophyton mentagrophytes, Tinea corporis caused by Trichophyton rubrum, Tinea cruris caused by Epidermophyton floccosumin, Tinea cruris caused by Trichophyton mentagrophytes, Tinea cruris caused by Trichophyton rubrum, Tine a Pedis Caused by Epidermophyton floccosumin, Tinea pedis caused by Trichophyton mentagrophytes, Tinea pedis caused by Trichophyton rubrum, Vaginal candidiasis, Vulvovaginal candidiasis, Cutaneous candidiasis, Recalcitrant dermatosis, Tinea versicolor caused by Malassezia infection

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How conazole (ketoconazole) works.

Conazole (ketoconazole) interacts with 14-α-sterol demethylase, a cytochrome P-450 enzyme required for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased permeability of fungal cells due to the reduced amount of ergosterol present in the fungal cell membrane. This metabolic inhibition also results in the accumulation of 14α-methyl-3,6-diol, a toxic metabolite. An increase in membrane fluidity is also believed to lead to damage to membrane-bound enzyme systems, as the components become less compact.

Konazol (ketokonazol)

Tradename Konazol (ketokonazol)
Availability prescription only
Generic ketoconazole
Ketoconazole Other names Ketokonazol, Ketokonazol, Ketokonazol, Ketozol
Related drugs flukonazol, Diflukan, itrakonazol, anfotericina b, vorikonazol, Nizoral, Sporanox, Abelcet, Fungizone
Formula C26H28cl2norte4O4
Weight Average: 531,431
Monoisotope: 530.148760818
protein bond

Ketoconazole is approximately 84% bound to plasma albumin and another 15% bound to blood cells, meaning it is 99% bound to plasma.

groups Approved, under investigation
therapy class Medications for subcutaneous and systemic mycoses
available country Filipinke
Last update: June 22, 2022 at 11:59 p.m.


Konazole (Ketoconazole) Use, Dosage, Side Effects, FAQ - MedicinesFAQ (1)


  • Konazol (ketokonazol)
  • usos
  • Dose
  • Secondary effect
  • Precautions
  • interactions
  • Use during pregnancy
  • It is used during lactation.
  • precise overdose
  • Interaction with food
  • half life
  • volume of distribution
  • Descargar
  • Interaction with another drug
  • Contradiction
  • Store

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Dosis de conazol (ketoconazol)


fungal infections:

  • Adult:200mg once a day; it can be increased to 400 mg once daily if the clinical response is poor. Continue treatment until symptoms resolve and cultures are negative.
  • Niño:≥2 years 3.3-6.6 mg/kg once daily. Duration of treatment: 1-2 weeks for candidiasis; at least 4 weeks for resistant dermatophyte infections and up to 6 months for other systemic mycoses.
  • Elderly people:No dose adjustments are necessary.

Theme (For Adults)-

Pityriasis versicolor, fungal skin infections:

  • As 2% cream: Apply 1-2 times a day to cover the affected area and its surroundings for at least a few days after the symptoms disappear.
  • As 2% shampoo: Apply to the scalp once a day for a maximum of 5 days. For prophylaxis: Use as a 2% shampoo once a day for a maximum of 3 days before sun exposure.

Seborrheic dermatitis:

  • like 2% foam: Apply to the sensitive affected area for 4 weeks.
  • As shampoo 1 or 2%: Apply to the scalp twice a week for 2-4 weeks. For prophylaxis: As a 2% shampoo, use once every 1-2 weeks.

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Treatment duration

  • Tinnitus versicolor: 1 to 6 weeks
  • Dermatomycosis: 2 to 8 weeks
  • Onychomycosis: 1 to 12 months
  • Mycosis of the hair and scalp: 1 to 2 months
  • Chronic mucocutaneous candidiasis: 1 to 12 months
  • Oral mycoses: 5 to 10 days
  • Systemic candidiasis: 1 to 2 months
  • Paracoccidioidomicosis, histoplasmosis
  • and other systemic mycoses: 1 month to 2 years

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(Video) KETOCONAZOLE DRUG, USE, DOSE, SIDE EFFECTS, कीटोकोनाजोल एंटिफंगल की जानकारी सरल भाषा में, ANTIFUNGAL

Side effects

Konazole (ketoconazole) is very well tolerated. Occasionally, nausea and itching may occur. An idiosyncratic hepatic reaction may occur in some patients (incidence 1:10,000).


Overdose symptoms include acute liver damage, which may include hepatocellular and cholestatic damage, followed by anorexia, fatigue, nausea, and jaundice. In case of overdose, gastric lavage with activated charcoal can be used within an hour of taking ketoconazole; otherwise, provide supportive care. If the patient shows signs of adrenal insufficiency, give hydrocortisone 100 mg once with a saline and glucose infusion and monitor the patient closely. Blood pressure and fluid and electrolyte balance should be monitored over the next several days.

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a precaution

Predisposition to adrenocortical insufficiency. Apply with acid drink in patients with achlorhydria. Pregnancy and lactation.


Decreased absorption with antimuscarinics, antacids, H2 blockers, PPIs, and sucralfate. Reduced plasma concentrations with rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. It can also reduce concentrations of isoniazid and rifampicin. May reduce the effectiveness of oral contraceptives. May increase serum levels of CYP3A4 substrates, eg digoxin, oral anticoagulants, sildenafil, tacrolimus.

Interaction with food

  • Avoid alcohol. Drinking alcohol while taking ketoconazole can cause liver damage.
  • Avoid multivalent ions. May reduce ketoconazole concentrations.
  • Take with food. Food reduces gastrointestinal irritation caused by ketoconazole.

Conazole (ketoconazole) Interaction with alcohol



Excessive use of alcohol or alcohol-containing products together with ketoconazole or levoketoconazole may increase the risk of liver damage.

Serious hepatotoxicity has been reported with levoketoconazole.

Fatal hepatotoxicity or the need for liver transplantation has been reported with oral ketoconazole, of which levoketoconazole is an enantiomer.

Some patients had no obvious risk factors for liver disease.

Additionally, excessive use of alcohol or alcohol-containing products during ketoconazole or levoketoconazole therapy may cause a disulfiram-like reaction in some patients.

Symptoms of a disulfiram-like reaction include flushing, rash, peripheral edema, nausea, and headache.

In general, excessive alcohol consumption should be avoided during ketoconazole or levoketoconazole therapy.

Patients receiving ketoconazole or levoketoconazole should be instructed to contact their doctor immediately if they experience swelling, rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowish discoloration. of the skin or eyes. because they can be signs and symptoms of liver damage.

Conazole (ketoconazole) drug interactions

Moderate: polyethylene glycol 3350, polyethylene glycol 3350

Unknown: aspirin, aspirin, duloxetine, duloxetine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, pregabalin, pregabalin, paracetamol, paracetamol, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, cetirizine, cetirizine

Conazole (ketoconazole) interaction with pain

Address: hepatotoxicity

Moderate: QT prolongation, achlorhydria, adrenal insufficiency

(Video) Instructions to use Ketoconazole shampoo - Dr. Rasya Dixit

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volume of distribution

Conazole (ketoconazole) has an estimated volume of distribution of 25.41 L or 0.36 L/kg. It is widely distributed in tissues, reaching effective concentrations in skin, tendons, tears, and saliva. Distribution in vaginal tissue creates concentrations 2.4 times lower than in plasma. Penetration into the CNS, bone, and seminal fluid is minimal. Animal studies have shown that conazole (ketoconazole) passes into breast milk and crosses the placenta.

removal path

Conazole (ketoconazole) requires an acidic environment to become soluble in water. At pH values ​​above 3, it becomes increasingly insoluble and about 10% dissolves in 1 h. At pH less than 3, dissolution is 85% complete in 5 minutes and complete in 30 minutes. A single oral dose of 200 mg gives a Cmax of 2.5 to 3 mcg/mL with a Tmax of 1 to 4 hours. Administration of ketoconazole with food consistently increases Cmax and delays Tmax, but the literature is conflicting regarding the effect on AUC, which may be slightly reduced. A bioavailability of 76% has been reported for ketoconazole.

half life

Conazole (ketoconazole) exhibits biphasic elimination with a first phase half-life of 2 hours and a terminal half-life of 8 hours.

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Conazole (ketoconazole) has an estimated clearance of 8.66 L/h.

removal path

Only 2-4% of the ketoconazole dose is excreted unchanged in the urine. More than 95% is eliminated by metabolism in the liver.

Use in pregnancy and lactation.

Category C: Animal studies have revealed harmful effects on the fetus (teratogenic, embryocidal or other) and there are no controlled studies in women or studies in women and animals. Drugs should only be given if the potential benefit justifies the potential risk to the fetus.

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hypersensitivity; existing liver disease. Concomitant use with CYP3A4 substrates, for example, HMG-CoA reductase inhibitors (for example, lovastatin, simvastatin), midazolam, triazolam, cisapride, dofetilide, eplerenone, nisoldipine, pimozide, quinidine, terfenadine, astemizole, ergot alkaloids (for example, ergotamine, dihydroergotamine).

special notice

Renal insufficiency: Oral: No dose adjustment required.

Liver failure:Oral method: Contraindicated.

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storage condition

Store at a temperature of 15-25° C. Protect from moisture and light.

monograph of innovators

You can find a simplified version hereKonazol (ketokonazol)

Konazol (ketokonazol) contains ketoconazole view innovator's full prescribing information Konazole (Ketoconazole) Monograph,Konazol (ketokonazol) MSDS,FDA label of konazole (ketoconazole)

(Video) Ketoconazole Cream, Gel, Lotion, Ointment and Soap - Drug Information

Common questions

What is conazole (ketoconazole) used for?

Conazole (ketoconazole) is an antifungal medication used to treat certain fungal infections. Conazole (ketoconazole) should only be used when you cannot use other antifungal medications. Conazole (ketoconazole) applied to the skin is used for fungal skin infections such as ringworm, cutaneous candidiasis, tinea versicolor, dandruff, and seborrheic dermatitis.

Is conazole (ketoconazole) safe for humans?

Conazole (ketoconazole) tablets should not be used as the first choice for any fungal infection, as they can cause severe liver damage and adrenal gland problems, as well as harmful drug interactions.

How does Conazole (ketoconazole) work?

Conazole (ketoconazole) works by stopping the growth of fungi.

What are the common side effects of conazole (ketoconazole)?

    Common side effects of Conazol (Ketoconazole) include:

  • Acne
  • bleeding from a mouth wound
  • blistering, scabbing, irritation, itching, or redness of the skin
  • burning, tingling, itching, numbness, tingling, "pins and needles" or prickly sensations
  • cracked, dry, or flaky skin
  • change in color of fingernails or toenails
  • dizziness
  • dry, irritated or swollen eyes
  • red rash with watery, yellow, or pus-like blisters, with or without thick, honey-like crusts
  • dry skin, pain, rash, redness, or swelling
  • pain in the mouth or gums
  • Hichazon facial

Is conazole (ketoconazole) safe during pregnancy?

There are no controlled human pregnancy data, limited data indicate no adverse effects of this topical medication on pregnancy or fetal health. There are no known risks associated with the use of Conazol (ketoconazole) during pregnancy; no effect on the newborn is expected. Conazole (ketoconazole) should be used during pregnancy only if the benefit outweighs the risk to the fetus.

Is conazole (ketoconazole) safe while breastfeeding?

Because there is little published experience with Conazol (ketoconazole) during lactation and its possible inhibition of liver enzymes and hepatotoxicity, other drugs may be better. However, if the mother needs oral conazole (ketoconazole), this need not be a reason to stop breastfeeding.

Can I drink alcohol with Conazol (ketoconazole)?

Do not drink alcoholic beverages while taking Conazol (ketoconazole), as drinking alcoholic beverages may increase the risk of developing liver damage.

Can I drive after taking Conazol (ketoconazole)?

You may feel sleepy or dizzy. Do not drive, use machines, or do anything that requires mental alertness until you know how this medicine works for you.

When should Konazole (ketoconazole) be taken?

Conazole (ketoconazole) can be taken with or without food, but taking it with food helps reduce stomach upset. If you take an antacid, take Conazole (Ketoconazole) at least 2 hours before or 1 hour after taking an antacid; otherwise, the body may not absorb Conazole (Ketoconazole).

(Video) 7 दिन मे Dandruff झड़ना रोके | 5 Benefits of Ketoconazole Shampoo

How long does it take for conazole (ketoconazole) to take effect?

Conazole (ketoconazole) usually works within 2 to 3 weeks for most fungal infections, but athlete's foot can take up to 6 weeks to get better.

Can Conazol (ketoconazole) be used long term?

Do not use more, do not use more often, and do not use for longer than prescribed by your doctor. This can cause unwanted side effects or skin irritation.

How long can I take Conazol (ketoconazole)?

You may need to take Conazol (ketoconazole) for 6 months or longer to completely clear up the infection.

When should I not use Ketoconazole?

Do not use near high temperatures or open flames or while smoking.

Can I use too much Conazol (ketoconazole)?

Do not use more, do not use more often, and do not use for longer than prescribed by your doctor. This can cause unwanted side effects or skin irritation.

Will Conazole (ketoconazole) affect my fertility?

There is no evidence to suggest that applying Conazol (ketoconazole) to the skin reduces male fertility.

Is conazole (ketoconazole) good for face?

Conazole (ketoconazole) cream should only be applied as recommended by your doctor. If you need to apply Conazol (ketoconazole) cream to your face, you can, just be careful not to get it in your eyes.

Can conazole (ketoconazole) make the rash worse?

Conazole (ketoconazole) strong over-the-counter steroid creams that contain combinations of antifungal and antibacterial drugs can make ringworm worse and cause other health problems.

Does Conazole (ketoconazole) help with hair loss?

Conazole (ketoconazole) is also used as a treatment for androgenic alopecia in men and women.

Can topical conazole (ketoconazole) harm the liver?

Conazole (ketoconazole) can cause liver damage, sometimes severe enough to require a liver transplant or cause death. Liver damage can occur in people who do not already have liver disease or any other condition that increases the risk of developing liver damage.

(Video) KETOCONAZOLE cream | Lotion/Shampoo (हिंदी में),uses, side effects | Nizral cream/ketostar cream

What happens if I miss a dose of Conazol (ketoconazole)?

If you forget to take a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Take your next dose at the usual time. Do not double the dose to compensate.


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