Press Release: Late Stage 3 COPD Results for Dupixent® (dupilumab) Presented at ATS and Simultaneously Published in the New England Journal of Medicine | market filter (2023)

Dupicente®(dupilumab) COPD Phase 3 Late Results Presented at ATS isimultaneouslyit was not publishedNew England Journal of Medicine

  • Dupixent is the first and only experimental COPD biologic to show a significant 30% reduction in moderate to severe acute exacerbations compared to placebo
  • Dupixent is the first and only experimental COPD biologic to significantly improve lung function at weeks 12 and 52, with numerical improvements seen at 2 weeks
  • Dupixent significantly improved quality of life, with numerical improvements as early as 4 weeks after treatment initiation and respiratory symptoms
  • COPD is the third leading cause of death worldwide, with no new approved treatment approaches for more than a decade; the study included patients with moderate to severe disease and evidence of type 2 inflammation (ie, blood eosinophils ≥300 cells/µL)

ParismiTarrytown, New York May 21,2023. Positive results of the evaluation of the 3rd phase of the use of the Dupixent test®(dupilumab) compared with placebo in adults currently receiving maximum standard inhaled therapy (triple therapy) with uncontrolled chronic obstructive pulmonary disease (COPD) and evidence of type 2 inflammation published today in 2023.International Conference of the American Thoracic Society (ATS)session "New England Journal of Medicine and JAMA". Debate on the Edge: Reports on Latest Published Pulmonary Research” and published simultaneously the no.New England Journal of Medicine(NEJM). These results will also be presented in the "Latest News: Results of Clinical Trials in Pulmonary Medicine" section onMay 22nd.

surya bhatt, MD, MSPH
Associate Professor inuniversity of alabamaYeahBirmingham Pulmonary Unit, allergy and critical care medicine and study co-principal investigator
"I have seen patients with uncontrolled chronic obstructive pulmonary disease struggle for a long time with the debilitating symptoms of this progressive disease.with limited and gradual improvement over current treatment options. This study showed that dupilumab has the potential tostrikera vicious cycle of exacerbations and weakening of lung functionthey patients with uncontrolled COPD with type 2 inflammation,and significantly improve breathingsymptoms. Dupilumab also helped improve measures of health-related quality of life,OMS,of mineyear ofexperience as a doctor, they arejust as important to patients as the ability to breathe better.”

COPD is a life-threatening respiratory disease that damages the lungs and causes a progressive decline in lung function. Symptoms include a persistent cough and shortness of breath that can not only affect the ability to perform routine daily activities, but can also lead to anxiety, depression, and sleep disturbances. COPD is also associated with a significant health and economic burden due to repeated acute exacerbations that require treatment with systemic corticosteroids and/or lead to hospitalization or even death. Smoking and exposure to particulate matter are the main risk factors for COPD, but even people who quit smoking can develop or continue to develop the disease. inNAS.only about 300,000 people are living with uncontrolled COPD with evidence of type 2 inflammation.

Results presented in ATS and published inNEJMare from the BOREAS trial, which met the primary endpoints and all primary secondary endpoints. As shown and reported, patients receiving Dupixent (n=468) compared to placebo (n=471) added to maximal standard triple inhalation therapy experienced:

  • 30% reduction in moderate to severe acute exacerbations of COPD over 52 weeks (p<0.001), primary endpoint.
  • 160 mL improvement in lung function from baseline at 12 weeks vs. 77 mL (p<0.001).
    • Numerical improvements were observed at 2 weeks, and the benefit over placebo was maintained at 52 weeks (Dupixent: 153 mL, placebo: 70 mL; p<0.001).
  • An improvement in health-related quality of life (QoL) of 9.7 points from baseline at 52 weeks vs. an improvement of 6.4 points (p = 0.002), with numerical values ​​of improvement observed at 4 weeks.
  • A 2.7-point reduction in respiratory symptom severity (patient-reported outcome on a scale of 0 to 40) from baseline to week 52 vs. a 1.6-point reduction (p=0.001).

In a prespecified subgroup analysis of patients (Dupixent n=195, placebo n=188) with elevated levels (≥20 ppb) of fractionated exhaled nitric oxide (FeNO), a biomarker of type 2 inflammation in the airways, treatment with Dupixent also led to a significant 38% reduction in exacerbations compared to placebo at 52 weeks (p = 0.005). In this subgroup, Dupixent also produced a lung function improvement of 232 mL vs. placebo 108 mL at 12 weeks (p = 0.002) which was maintained at 52 weeks with a lung function improvement of 247 mL vs. 120 ml of the placebo (p = 0.003).

The safety results were generally consistent with the known safety profile of Dupixent in its approved indications. The overall adverse event (AE) rates were 77% for Dupixent and 76% for placebo. More frequently observed adverse events with Dupixent compared to placebo included headache (8.1% Dupixent, 6.8% placebo), diarrhea (5.3% Dupixent, 3.6% placebo), and back pain. (5.1% Dupixent, 3.4% placebo). More frequently observed adverse events with placebo compared with Dupixent included upper respiratory tract infection (9.8% placebo, 7.9% Dupixent), hypertension (6.0% placebo, 3.6% Dupixent ) and COVID-19 (5.7% placebo, 4.1% Dupixent). Adverse events leading to death were balanced between the two groups (1.7% placebo, 1.5% Dupixent).

A second Phase 3 repeat study of Dupixent in COPD with evidence of type 2 inflammation (NOTUS) is ongoing, with data expected in 2024. The safety and efficacy of Dupixent in COPD is currently under clinical investigation and not It has not been evaluated by any regulatory body. .sanofiand Regeneron hope to discuss the BOREAS data with regulators.

About EPOC Dupixentphase 3exam program
BOREAS is one of the two main tests in the Dupixent COPD programme. A Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of Dupixent in 939 adult smokers or ex-smokers aged 40 to 80 years with moderate to severe COPD. All patients in the study had evidence of type 2 inflammation, as measured by blood eosinophils ≥300 cells/µL. Patients with a diagnosis or history of asthma were excluded from the study. During the 52-week treatment period, patients received either Dupixent or placebo every two weeks, in addition to maximum standard inhaled triple therapy of inhaled corticosteroids (ICS), long-acting beta-agonists, and long-acting muscarinic antagonists. Dual maintenance therapy was allowed if ICS were contraindicated.

The primary endpoint assessed the annual rate of moderate or severe acute exacerbations of COPD. Moderate exacerbations are defined as those requiring systemic administration of steroids and/or antibiotics. Serious exacerbations are defined as those: requiring hospitalization; requires more than one day of observation in an emergency department or urgent care center; or results in death.

Primary secondary endpoints and other hierarchical endpoints include:

  • Change from baseline in lung function (assessed by forced expiratory volume in one second [FEV1] before bronchodilator) at weeks 12 and 52 in both the general population and those with FeNO ≥ 20 ppb.
  • Change from baseline at week 52 in St. George's (SGRQ) compared with placebo (0-100 scale).
  • Change from baseline after 52 weeks in COPD Respiratory Symptom Rating Scale (E-RS: COPD) score (range 0-40).
  • Annual rate of moderate or severe acute exacerbations of COPD in patients with FeNO ≥ 20 ppb.

OjosanofimiRegeneron CPODclinical research program
sanofiand Regeneron are motivated to transform the COPD treatment paradigm by examining the role that different types of inflammation play in disease progression through investigation of two potentially pioneering biologics, Dupixent and Itepekimab.

Dupixent inhibits the interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling pathway, and the program targets a specific population of people with evidence of type 2 inflammation. Itepequimab is a monoclonal antibody fully human that binds to and inhibits interleukin-33 (IL-33), an initiator and enhancer of systemic inflammation in COPD. Both programs have four ongoing Phase 3 trials designed to inform next-generation treatments for people with COPD who may not have other options.

Itepequimab is currently undergoing clinical investigation and its safety and efficacy have not been evaluated by any regulatory body.

O Dupixentu
Dupixent is a fully human monoclonal antibody that inhibits the interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling pathways and is not immunosuppressive. The Dupixent development program demonstrated significant clinical benefit and reduction in type 2 inflammation in phase 3 trials, establishing that IL-4 and IL-13 are key drivers of type 2 inflammation, which plays an important role in multiple related diseases and often comorbidities. Those conditions include approved indications for Dupixent such as atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), eosinophilic esophagitis (EoE), and prurigo nodules.

Dupixent has received regulatory approvals in one or more countries worldwide for use in certain patients with atopic dermatitis, asthma, CRSwNP, EoE, or prurigo nodulares in various age populations. Dupixent is currently approved for one or more of these indications in more than 60 countries, includingEuropa, oNAS.miJapan. More than 600,000 patients are treated with Dupixent worldwide.

Dupilumab Development Program
Dupilumab is being co-developedsanofiand Regeneron under a global collaboration agreement. To date, dupilumab has been studied in more than 60 clinical trials involving more than 10,000 patients with various chronic diseases caused in part by type 2 inflammation.

With currently approved indications,sanofiand Regeneron are studying dupilumab in a broad range of diseases caused by type 2 inflammation or other allergic processes in phase 3 trials, including pediatric EoE, chronic spontaneous urticaria, chronic pruritus of unknown origin, chronic obstructive pulmonary disease with evidence of type 2 inflammation. 2, and bullous pemphigoid. These potential uses of dupilumab are currently under clinical investigation, and safety and efficacy in these conditions have not been fully evaluated by any regulatory body.

About Regeneron
Regeneron (NASDAQ: REGN) is a leading biotechnology company that invents, develops and markets life-changing medicines for people with serious illnesses. Founded and led for 35 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and multiple product candidates in development, nearly all developed in our laboratories. Our line of medicines and products is designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, pain, hematological conditions, infectious diseases and rare diseases.

Regeneron accelerates and improves the traditional drug development process through ourfast apartments®technologies, such asVelocImune®, which uses unique genetically humanized mice to produce optimized fully human and bispecific antibodies, and through ambitious research initiatives such as the Regeneron Genetics Center, which leads one of the world's largest gene sequencing efforts.

For more information, visit or follow @Regeneron on Twitter.

We are an innovative global healthcare company, driven by one purpose: to pursue the wonders of science to improve people's lives. Our team, in nearly 100 countries, is dedicated to transforming the practice of medicine by working to make the impossible possible. We bring life-changing treatment options and life-saving vaccine protection to millions of people around the world, placing sustainability and social responsibility at the heart of our ambitions.

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Press Release: Late Stage 3 COPD Results for Dupixent® (dupilumab) Presented at ATS and Simultaneously Published in the New England Journal of Medicine | market filter (1)

Press Release: Late Stage 3 COPD Results for Dupixent® (dupilumab) Presented at ATS and Simultaneously Published in the New England Journal of Medicine | market filter (2)

Press Release: Late Stage 3 COPD Results for Dupixent® (dupilumab) Presented at ATS and Simultaneously Published in the New England Journal of Medicine | market filter (3)


Sanofi-Aventis Group

2023 GlobeNewswire, Inc., sourcePress releases


What are the results of the DUPIXENT COPD trial? ›

“This trial showed that dupilumab has the potential to impact the vicious cycle of exacerbations and lung function decline in patients with uncontrolled COPD with type 2 inflammation, and significantly improve respiratory symptoms.

Does DUPIXENT work for COPD? ›

Dupixent is the first and only biologic to demonstrate a clinically meaningful and highly significant reduction (30%) in moderate or severe acute exacerbations of COPD (rapid and acute worsening of respiratory symptoms), while also demonstrating significant improvements in lung function, quality of life and COPD ...

Does DUPIXENT improve lung function? ›

DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems.

How do you help someone with COPD? ›

How Do I Help My Loved One Manage Their COPD?
  1. Help them quit. The top cause of COPD is tobacco smoking. ...
  2. Get active with them. ...
  3. Keep yourself healthy. ...
  4. Keep indoor air clean. ...
  5. Help make their house COPD-friendly. ...
  6. Go along to their doctor's appointments. ...
  7. Educate yourself about COPD. ...
  8. Learn how to recognize signs of distress.
May 21, 2019

How quickly do you see results with DUPIXENT? ›

Bottom Line. In adults and children, Dupixent (generic name: dupilumab) can start to work as quickly as 2 to 4 weeks to relieve itching due to eczema lead to a clear or almost clear skin improvement in 16 weeks.

Can DUPIXENT cause lung problems? ›

Examples of these include pneumonia (a lung condition) and vasculitis (inflammation of blood vessels). Although rare, in early studies of Dupixent, these conditions were reported in people who took the drug to treat asthma.

What is the COPD treatment 2023? ›

Jan 25, 2023 A Breakthrough Treatment for COPD

Zephyr Valves received breakthrough device designation and were approved by the Food and Drug Administration in 2018 to help patients with severe COPD and emphysema breathe easier without many of the risks associated with major surgery.

Which drug improve survival of COPD? ›

(See "Role of muscarinic antagonist therapy in COPD".) Individually, albuterol and ipratropium have been compared in randomized trials [13,16,17]. On average, both medications improve lung function to a similar degree, although the effects may vary [18].

What is the best medication for severe COPD? ›

A medication approved for people with severe COPD and symptoms of chronic bronchitis is roflumilast (Daliresp), a phosphodiesterase-4 inhibitor. This drug decreases airway inflammation and relaxes the airways. Common side effects include diarrhea and weight loss.

Is DUPIXENT safe to take long term? ›

But in rare cases, the drug can cause side effects that may be long lasting. These include eye-related side effects, such as changes in vision and new or worsening eye conditions. Long lasting side effects may also include eosinophilic conditions such as vasculitis (swelling and inflammation of blood vessels).

Is DUPIXENT safe long term? ›

Dupixent Safe, Effective Up to Four Years in Adults With Moderate-to-Severe Atopic Dermatitis. Safe and effective long-term treatment is important for stable disease control in atopic dermatitis.

Do you have to use DUPIXENT forever? ›

How long do I have to take Dupixent? Because of the chronic (recurring) nature of atopic dermatitis, you must remain on Dupixent to continue the clinical benefits of the drug.

What is the average age of death with COPD? ›

Many people will live into their 70s, 80s, or 90s with COPD.” But that's more likely, he says, if your case is mild and you don't have other health problems like heart disease or diabetes. Some people die earlier as a result of complications like pneumonia or respiratory failure.

How can I strengthen my lungs with COPD? ›

Practice holding a gentle stretch for 10 to 30 seconds, slowly breathing in and out. Repeat this a few times. Aerobic exercise is good for your heart and lungs and allows you to use oxygen more efficiently. Walking, biking and swimming are great examples of aerobic exercise.

How do you live a full life with COPD? ›

The exact length of time you can live with COPD depends on your age, health, and symptoms. Especially if your COPD is diagnosed early, if you have mild stage COPD, and your disease is well managed and controlled, you may be able to live for 10 or even 20 years after diagnosis.

What is the downside of DUPIXENT? ›

The most common side effects of DUPIXENT include:

eye and eyelid Inflammation, including redness, swelling, and itching, sometimes with blurred vision. cold sores in your mouth or on your lips. high count of a certain white blood cell (eosinophilia)

What is DUPIXENT success rate? ›

ADULTS 18+ years of age
Secondary endpoint EASI-75: ≥75% improvement in lesion extent and severity (% of patients)
69% (P<0.0001)23%
Secondary endpoint ≥4-point improvement in: Peak Pruritus NRS (in adultsh and children) or Worst Scratch/Itch NRS (in infants to preschoolers) (% of patients)
59% (P<0.0001)20%
4 more rows

Why is DUPIXENT so expensive? ›

Dupixent's cost may also be higher because it's an injectable medication and may only be available through specialty pharmacies. And in some cases, you need to visit your doctor to receive a dose. To learn more about ways to save on the cost of Dupixent, see the “Can I get help paying for Dupixent?” section below.

Is Dupixent toxic to the liver? ›

Does Dupixent cause liver damage? Many studies have reported that Dupixent does not cause any serious effects on the liver. No study has reported clinically apparent acute liver injury attributed to dupilumab therapy. Dupilumab is a human monoclonal antibody and is unlikely to damage the liver.

Does Dupixent weaken your immune system? ›

Dupixent isn't known to weaken your immune system in a way that makes it easier for you to get infections. Instead, the drug reduces inflammation signals in your immune system that can cause eczema, asthma, and chronic sinusitis. (These are conditions Dupixent is used to treat.)

How to get Dupixent for free? ›

The DUPIXENT MyWay Patient Assistance Program can also help if you are uninsured or your insurance doesn't cover DUPIXENT. Patients will need to meet the eligibility criteria, including household income, to qualify. The DUPIXENT MyWay team will research each patient's situation and determine eligibility.

Is there a cure for Stage 3 COPD? ›

Most experts agree that there's no cure for the disease at this time. Still, there is a lot you can do to improve the way you feel and to slow down the progression of your symptoms. It's important to keep up to date with flu and pneumonia vaccines to prevent illnesses.

How close is a cure for COPD? ›

There is no cure for COPD, but treatment options may help you: Better control symptoms. Slow the progression of the disease. Reduce the risk of exacerbations or flare ups.

Is there no cure for end stage COPD? ›

According to the American Lung Association, COPD is the third most common cause of death in the United States. There is no cure for COPD, but medications and lifestyle changes can help reduce symptoms and slow down the progression of the disease.

Has anyone ever beat COPD? ›

There is no cure for COPD, but disease management can slow disease progression, relieve symptoms and keep you out of hospital. Treatment aims to prevent further damage, reduce the risk of complications and ease some of the symptoms. Treatment options include pulmonary rehabilitation, medicines and oxygen therapy.

What is the new surgery for COPD? ›

One of the newest treatment options for severe emphysema is a minimally invasive procedure called bronchoscopic lung volume reduction (BLVR) using endobronchial valves. These tiny devices are implanted in the airways of the lungs and act as one-way valves.

Is there any hope for COPD patients? ›

Is COPD curable? There is no cure for chronic obstructive pulmonary disease (COPD), but treatment can help manage the symptoms and slow the progression of the disease. COPD is a progressive lung disease that includes chronic bronchitis, emphysema, and sometimes asthma symptoms.

What is the best treatment for stage 3 COPD? ›

Treatments include: stopping smoking – if you have COPD and you smoke, this is the most important thing you can do. inhalers and tablets – to help make breathing easier. pulmonary rehabilitation – a specialised programme of exercise and education.

What is the most severe COPD? ›

End stage COPD is the most severe stage. It can lead to death. According to the Centers for Disease Control and Prevention , chronic lower respiratory diseases — of which COPD is the most prevalent — were the sixth leading cause of death in the United States in 2022.

What is the fastest relief for COPD? ›

Quick relief Muscarinic antagonists (anti-cholinergics)

There is one medicine, ipratropium (Atrovent), which works slower than beta-agonists, but faster than other long-acting medicines.

Is Dupixent worth the risk? ›

Dupixent doesn't totally clear the risk of future eczema outbreaks, but it succeeds in managing symptoms,” he said. “Most of my patients experience less itching, a reduction in the rash, better sleep and a better quality of life overall.” But Dupixent isn't a cure, and it's not perfect.

How long do you need to stay on Dupixent? ›

Dupilumab is an ongoing treatment rather than a treatment that is used for a fixed amount of time. Patients are reviewed after 16 weeks to see how effectively the treatment is working for them. If a patient's eczema has not responded adequately to dupilumab after 16 weeks, the treatment may be stopped.

How long does the Dupixent injection last? ›

In adults and children 6+ years and older, your initial dose of DUPIXENT is 2 injections under the skin (subcutaneous injection) at different injection sites. After that, it is taken as 1 injection every 2 weeks or every 4 weeks, depending on your age and weight, at different injection sites.

Can you drink alcohol on Dupixent? ›

You may wonder whether you can drink alcohol while using Dupixent. There aren't any known interactions between alcohol and Dupixent.

Can Dupixent cause neuropathy? ›

Dupilumab improved asthma symptoms, but it was discontinued owing to sustained peripheral neuropathy. Numbness resolved 6 months after withdrawal of dupilumab. The clinical course of our patient clearly suggests a direct association between the development of peripheral neuropathy and administration of dupilumab.

Does Dupixent have a lower age limit? ›

DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies.

How long can you take dupilumab for? ›

The recommended dose of dupilumab for adult patients is an initial dose of 300 mg followed by 300 mg given every other week. Dupilumab is intended for long-term treatment. Consideration should be given to discontinuing treatment in patients who have shown no response after 24 weeks of treatment for CRSwNP.

Can you take prednisone while on Dupixent? ›

No interactions were found between Dupixent and prednisone.

What happens if you get a live vaccine on Dupixent? ›

Avoid use of live vaccines in patients treated with DUPIXENT. It is unknown if administration of live vaccines during DUPIXENT treatment will impact the safety or effectiveness of these vaccines.

What are the dying stages of COPD? ›

As a person approaches the end of life, they may experience the following:
  • Shortness of breath while resting.
  • Trouble with activities of daily living: walking, cooking, dressing, or doing other daily activities.
  • Chronic respiratory failure. ...
  • Respiratory infections, such as flu and pneumonia, can worsen COPD.

Can COPD patients live 30 years? ›

Some people can live with mild or moderate COPD for decades. Other people may be diagnosed with more advanced COPD and progress to very severe disease much faster. Some of this boils down to genetics. But some of it is due to how much you smoke or smoked and the level of lung irritants you are exposed to.

Can you live a long life with stage 4 COPD? ›

With proper treatment, the disease doesn't have to limit how long you live, even if it's severe COPD.

What's the best exercise for COPD? ›

The best types of physical exercise for COPD are stretching, aerobic exercise, and resistance training. The best breathing exercises include pursed lip breathing and diaphragmatic breathing. Tai chi and yoga, which combine physical activity and breathing work, are often also beneficial.

Can lungs regenerate from COPD? ›

Several medications with bronchodilating and/or anti-inflammatory effects have been developed and prescribed in clinical practice. However, although many studies have tried to regenerate destroyed alveoli, no therapy has successfully repaired the diseased lungs of patients with COPD.

Can a person with COPD increase lung capacity? ›

Patients with chronic obstructive pulmonary disease (COPD) exhibit increases in lung volume due to expiratory airflow limitation. Increases in lung volumes may affect upper airway patency and compensatory responses to inspiratory flow limitation (IFL) during sleep.

What is the life expectancy of someone with stage 3 COPD? ›

Stage 3 COPD life expectancy is 5.8 years. The same study also found that female smokers lost about five years of their lives at this stage.

What should people with COPD not do? ›

Since people with COPD have more sensitive lungs, being around any type of irritant can make the condition worse. Avoid things like secondhand smoke, air pollution, dust and fumes from chemicals, paint or cleaning products, as well as mold and mildew.

What is the result of DUPIXENT? ›

The majority of adult patients saw significant skin improvement and itch reduction at 1 year of treatment with DUPIXENT when used with topical corticosteroids.

Does DUPIXENT help with shortness of breath? ›

DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems.

Can I live 20 years with COPD? ›

Especially if your COPD is diagnosed early, if you have mild stage COPD, and your disease is well managed and controlled, you may be able to live for 10 or even 20 years after diagnosis.

What is the downside of Dupixent? ›

The most common side effects of DUPIXENT include:

eye and eyelid Inflammation, including redness, swelling, and itching, sometimes with blurred vision. cold sores in your mouth or on your lips. high count of a certain white blood cell (eosinophilia)

How long can you stay on Dupixent? ›

Dupixent Safe, Effective Up to Four Years in Adults With Moderate-to-Severe Atopic Dermatitis.

Why is Dupixent so expensive? ›

Dupixent's cost may also be higher because it's an injectable medication and may only be available through specialty pharmacies. And in some cases, you need to visit your doctor to receive a dose. To learn more about ways to save on the cost of Dupixent, see the “Can I get help paying for Dupixent?” section below.

What are the long term side effects of Dupixent? ›

The most common side effects encountered during dupilumab therapy were head and neck dermatitis in 25 (19.5%), conjunctivitis in 20 (15.6%), erythema, pruritus and peeling of skin in 14 (10.9%) and dryness of eyes in 10 (7.8%) patients, respectively.

What are the worst states to live in if you have COPD? ›

Worst cities for living with COPD
  • Fairbanks, Alaska.
  • Visalia-Porterville-Hanford, California.
  • Bakersfield, California.
  • Los Angeles-Long Beach, California.
  • Fresno-Madera, California.
  • Modesto-Merced, California.
  • El Centro, California.
  • Lancaster, Pennsylvania.

What state is the best place to live with COPD? ›

The thin air you'll find at high altitudes makes it difficult to get the oxygen you need. Lower elevations such as those you find in Florida make breathing easier when you have COPD. Overall, Florida shines when it comes to providing a good quality of life for those with COPD.

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